Bone tissue reaction, setting time, solubility, and pH of root repair materials


This study aims to compare the bone tissue reaction, setting time, solubility, and pH of NeoMTA Plus, Biodentine (BD), and MTA Angelus (MTA-A).


Initial and final setting times (n = 7) and solubility up to 7 days (n = 11) were evaluated in accordance with ASTM C266–15 and ANSI/ADA Specification No. 57, respectively. pH (n = 10) was measured up to 28 days. Bone tissue reactions in 48 rats’ femur were histologically analyzed after 7, 30, and 90 days. ANOVA and Tukey’s tests compared setting time, solubility, and pH data; bone reactions data were compared by Kruskal-Wallis and Dunn’s tests.


NeoMTA Plus had longer initial and final setting times than MTA-A and BD (P < 0.05). At 7 days, BD showed the highest solubility, similar to NeoMTA Plus (P > 0.05) and different from MTA-A (P < 0.05). NeoMTA Plus had a progressive mass loss over time; at 7 days, it was significantly different from the initial mass (P < 0.05). BD showed higher pH in the periods assessed when compared to the other materials (P < 0.05). Bone tissue repair had no differences between groups in each experimental period (P > 0.05). All groups presented no difference from 30 to 90 days (P > 0.05) and had better bone repair at 90 days than at 7 days (P < 0.05).


NeoMTA Plus, BD, and MTA-A showed satisfactory setting time, high mass loss, alkaline pH, and allowed bone repair.

Quintana RM, Jardine AP, Grechi TR, et al. Bone tissue reaction, setting time, solubility, and pH of root repair materials. Clin Oral Investig. 2019;23(3):1359-1366. doi:10.1007/s00784-018-2564-1.

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